![]() Co-authors are Shane Gonen, a postdoctoral scholar at UC San Francisco and Tamir Gonen, a professor of biological chemistry and physiology at the UCLA David Geffen School of Medicine and a Howard Hughes Medical Institute Investigator. Yeates praised as “spectacular” the research of lead author Yuxi Liu, a UCLA graduate student in his laboratory. Seeing the defect can provide an understanding of what causes diseases, which can lead to new pharmaceuticals and treatments for diseases. Many diseases are due to a mutation or defect in a protein. Although a scaffold may have been initially safe, it can become damaged over time, compromising the integrity of the construction. When you see it, you frequently think, now I see how it does what it does.” “A picture is worth 1,000 words, and very often, getting a first three-dimensional view of a component of the cell gives you valuable insight - often surprising and unexpected - that you could not anticipate. “The last 50 years of structural biology has been about trying to get detailed pictures of all the parts of the cell to understand them thoroughly,” Yeates said. is a San Francisco company that assists contractors by erecting quality scaffolding for any project. Why is it so important to see a protein in such detail? The development of cryo-electron microscopy earned Jacques Dubochet, Joachim Frank and Richard Henderson the 2017 Nobel Prize in Chemistry. ![]() “The small protein we attached can itself be made to bind to other proteins, which can then be studied by cryo-electron microscopy,” said Yeates, whose research team is currently working on doing this. Their new method, which Yeates calls “scaffolding,” can be modified easily to bind to many different proteins as a “universal protein scaffold.” But when the researchers attached the copies to the protein cage, they succeeded in seeing the DARPin with cryo-electron microscopy.Ī challenge the researchers overcame was getting the copies of the protein to attach in a rigid manner. serves the Greater San Francisco Bay Area in sales, rental, and installation of steel scaffolding and laminated plank. ![]() The small protein, called a DARPin, is too small to analyze using cryo-electron microscopy alone. In the new research, his team used “protein engineering” to attach 12 copies of a small protein to a cube-shaped molecular cage, which was designed by a former graduate student of Yeates’. Yeates’ research team published the first research, in 2001, in the scientific field of designing molecular cages built from protein molecules. Image depicts molecular “scaffolding.” The molecular cage is in yellow and blue the DARPin protein is in red. ![]()
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